With ARIsTADA® (aripiprazole lauroxil),
I don’t have to take a pill every day

KEIRA: I like writing because you can go anywhere, be anything, be anyone. It’s helped me have a safe and healthy outlet to express myself. I don’t really remember a time in my life where I didn’t have any symptoms. I have always struggled with paranoia, anxiety, and depression. When I was younger, I didn’t realize really anything was wrong. It was really when I started getting older, I realized it wasn’t what other people experience. That’s when my writing became extremely dark. The voices in my head and the hallucinations got really bad.

JENNIFER: Keira was always extremely smart. She read and could write before she was 3. But very timid. She didn’t engage in conversation unless somebody spoke to her, but I just thought she was an introvert and didn’t think anything was wrong until her junior year of high school. When she was 17, she went away in the summertime for a few weeks, and I saw a different side of her. She was writing me some letters, you know, and sending me messages that I thought were really dark. And when she returned home, things just continued to get worse.

KEIRA: I remember that I had a really bad breakdown my senior year of high school. And that’s when I had my first hospitalization. After that, I was in and out of the hospital constantly. At first doctors thought it was just depression and anxiety. Then the diagnoses kept changing over time. It was a really dark chapter of my life.

JENNIFER: Keira didn’t show any emotion. She walked around with a flat affect. The paranoia got worse. Her writings became really scary. She was becoming violent and started hurting herself. Everyone assumed she was just on drugs or alcohol, it was really frustrating. It made me realize there is such need for education on this topic, especially in her age group. I’m an ER nurse, so I know the drill. I knew she wasn’t taking drugs, so I kept pressing for answers.

KEIRA: When I was first hospitalized, I wasn’t completely open and honest with the nurses and doctors, because the voices in my head told me not to talk about them, and I was scared. In the summer of 2019, when I was 25 years old, I was hospitalized again. I decided to finally be more open and honest to get the proper help I needed. I realized the doctors and the nurses there were all just trying to help me. The psychiatrist at the hospital took some time to evaluate me. He talked to me about the symptoms I was having and then diagnosed me with schizophrenia. I was afraid, but I also had a sense of relief to finally know what was going on. I think deep down I had always suspected, but I just didn’t want to admit it.

JENNIFER: I didn’t understand schizophrenia and what it would mean for my daughter’s future. And then, we found out about ARISTADA.

KEIRA: The psychiatrist who diagnosed me with schizophrenia recommended ARISTADA. He told us ARISTADA is an injection with an option to receive it every 2 months. He told us about all the benefits and the risks, and after discussing it with my mom, I decided to try it.

NARRATOR: ARISTADA INITIO^® (aripiprazole lauroxil) and ARISTADA^® (aripiprazole lauroxil) may not be right for everyone.

ARISTADA INITIO is a prescription medicine given as a one-time injection and is used in combination with oral aripiprazole to start ARISTADA treatment, or re-start ARISTADA treatment after a missed dose, when ARISTADA is used for the treatment of schizophrenia in adults.

ARISTADA is a prescription medicine given by injection by a healthcare professional and used to treat schizophrenia in adults.

It is not known if ARISTADA INITIO and/or ARISTADA are safe and effective in children under 18 years of age.

Elderly people with dementia-related psychosis are at increased risk of death when treated with antipsychotic medicines including ARISTADA INITIO and ARISTADA. ARISTADA INITIO and ARISTADA are not for the treatment of people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

Before you start treatment with ARISTADA INITIO and ARISTADA, tell your healthcare provider if you have ever taken Abilify^®, Abilify Maintena^®, or any aripiprazole product before. People who are allergic to aripiprazole or any of the ingredients in ARISTADA should not receive ARISTADA. People must first tolerate oral aripiprazole before receiving ARISTADA INITIO or ARISTADA.

The most common side effect of ARISTADA INITIO and ARISTADA includes feeling like you need to move to stop unpleasant feelings (akathisia). Tell your healthcare provider if you have any side effect that bothers you or does not go away.

When starting ARISTADA, you may receive a one-time injection called ARISTADA INITIO along with 30 mg of oral aripiprazole. In some cases, your doctor will have you start with 21 days of oral aripiprazole if ARISTADA INITIO is not right for you.

Please watch and consider the additional Important Safety Information contained in this video.

KEIRA: I started treatment and stayed in the hospital for about 2 weeks. I was released and then had a follow-up with my nurse shortly after, who I continue to see on an ongoing basis. I like that I don’t have to remember to take a pill every day. A nurse gives me my injections at home. Since starting on ARISTADA, I’ve noticed an improvement in my symptoms. This has just been my experience on ARISTADA. Yours may be different. Talk to your healthcare team about what may be best for you.

JENNIFER: I’m happy to see her doing better. She’s working with her healthcare team to stay on her treatment plan.

KEIRA: I do still have bad days every once in a while. But I have learned better coping skills and how to handle them better. It’s easier to talk about what I’m going through now. If I’m having a bad day, I talk to my mom, my best friend, or my brother. I’m getting back into volunteering at a horse farm, and I really enjoy my job as a dog groomer. In the future, I’d like to open my own dog grooming shop and publish a book.

JENNIFER: My advice to other families and caregivers going through this is to seek help. Keep pushing, you know. Don’t settle for an answer you don’t understand.

KEIRA: Thinking about the future is still very new to me. I’d tell my future self to keep her head up. Be proud of how far you’ve come. Let go of the past and just keep moving forward. The next chapter of my journey is unwritten. I don’t know what’s to come, and that’s okay.

NARRATOR: IMPORTANT SAFETY INFORMATION

Elderly people with dementia-related psychosis are at increased risk of death when treated with antipsychotic medicines including ARISTADA INITIO and ARISTADA. ARISTADA INITIO and ARISTADA are not for the treatment of people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

Contraindication: Do not receive ARISTADA INITIO or ARISTADA if you are allergic to aripiprazole or any of the ingredients in ARISTADA. Allergic reactions to aripiprazole have ranged from rash, hives and itching to anaphylaxis, which may include difficulty breathing, tightness in the chest, and swelling of the mouth, face, lips, or tongue.

ARISTADA INITIO and/or ARISTADA may cause serious side effects including:

• Cerebrovascular problems (including stroke) in elderly people with dementia-related psychosis that can lead to death.
• Neuroleptic malignant syndrome (NMS), a serious condition that can lead to death. Call your healthcare provider or go to the nearest hospital emergency room right away if you have some or all of the following signs and symptoms of NMS:
  • high fever
  • stiff muscles
  • confusion
  • sweating
  • changes in pulse, heart rate, and blood pressure
• Uncontrolled body movements (tardive dyskinesia). ARISTADA INITIO and ARISTADA may cause movements that you cannot control in your face, tongue, or other body parts. Tardive dyskinesia may not go away, even if you stop receiving ARISTADA. Tardive dyskinesia may also start after you stop receiving ARISTADA.
• Problems with your metabolism such as:
  • High blood sugar (hyperglycemia). Increases in blood sugar can happen in some people who receive ARISTADA INITIO and/or ARISTADA. Extremely high blood sugar can lead to coma or death. If you have diabetes or risk factors for diabetes (such as being overweight or a family history of diabetes), your healthcare provider should check your blood sugar before you receive ARISTADA INITIO and/or ARISTADA and during your treatment with ARISTADA.
    • Call your healthcare provider if you have any of these symptoms of high blood sugar:
      • feel very thirsty
      • need to urinate more than usual
      • feel very hungry
      • feel weak or tired
      • feel sick to your stomach
      • feel confused, or your breath smells fruity
  • Increased fat levels (cholesterol and triglycerides) in your blood
  • Weight gain. You and your healthcare provider should check your weight regularly.
• Unusual and uncontrollable (compulsive) urges. Some people taking aripiprazole have had strong unusual urges such as gambling that cannot be controlled (compulsive gambling). Other compulsive urges include sexual urges, shopping, and eating or binge eating. If you or your family members notice that you are having unusual strong urges, talk to your healthcare provider.
• Decreased blood pressure (orthostatic hypotension). You may feel lightheaded or faint when you rise too quickly from a sitting or lying position.
• Falls. ARISTADA INITIO and ARISTADA may make you sleepy or dizzy when standing which may make you at risk for falls and related injuries.
• Low white blood cell count
• Seizures (convulsions)
• Problems controlling your body temperature. Avoid becoming too hot or dehydrated. Do not exercise too much. In hot weather, stay inside in a cool place if possible. Stay out of the sun. Do not wear too much clothing or heavy clothing. Drink plenty of water.
• Difficulty swallowing

The most common side effects of ARISTADA INITIO and ARISTADA include restlessness or feeling like you need to move (akathisia). These are not all the possible side effects of ARISTADA INITIO and ARISTADA. You should tell your healthcare provider about any side-effects you have.

Do not drive, operate hazardous machinery, or do other dangerous activities until you know how ARISTADA INITIO and ARISTADA affect you. ARISTADA INITIO and ARISTADA may affect your judgment, thinking or motor skills.

Before receiving ARISTADA INITIO and ARISTADA tell your healthcare provider about all of your medical conditions, including if you:

• have not taken Abilify^®, Abilify Maintena^®, or any aripiprazole product before
• have or had heart problems or a stroke
• have diabetes or high blood sugar or a family history of diabetes or high blood sugar. Your healthcare provider should check your blood sugar before you receive ARISTADA INITIO and/or ARISTADA and during your treatment with ARISTADA
• have or had low or high blood pressure
• have or had seizures (convulsions)
• have or had a low white blood cell count
• have problems that may affect you receiving an injection in your buttocks or your arm
• are pregnant or plan to become pregnant. It is not known if ARISTADA INITIO and/or ARISTADA will harm your unborn baby. If you become pregnant while taking ARISTADA INITIO and/or ARISTADA, talk to your healthcare provider about registering with the National Pregnancy Registry for Atypical Antipsychotics. You can register by calling 1-866-961-2388, or visit http://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/
• are breastfeeding or plan to breastfeed. ARISTADA INITIO and/or ARISTADA can pass into your breast milk. It is not known if it may harm your baby. Talk to your healthcare provider about the best way to feed your baby if you receive ARISTADA INITIO and/or ARISTADA.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ARISTADA INITIO and ARISTADA and other medicines may affect each other causing possible serious side effects. Do not start or stop any medicines after you receive ARISTADA INITIO and ARISTADA without talking to your healthcare provider first.

If you have any questions about your health or medicines, talk to your healthcare provider. You are encouraged to report all side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information for ARISTADA INITIO and ARISTADA, including Boxed Warning, and Medication Guides for ARISTADA INITIO and ARISTADA at www.ARISTADA.com.